ZER induced nuclear localization of the transcription factor Nrf2 that binds to antioxidant response element (ARE) of the phase II enzyme genes, suggesting that ZER is a potential activator of the Nrf2/ARE-dependent detoxification pathway. Zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, a herbal plant which is also known as lempoyang. Enzymatic activation of initiator caspases leads to proteolytic activation of downstream (effector) caspases and cleavage of a number of vital proteins, resulting in the orderly demise and removal of the cell. The anticancer properties of zerumbone (2,6,9 humulatriene-8-one, a sesquiterpenoid) from Zingiber aromaticum were compared with those of curcumin from Curcuma longa in an in vitro MTT tetrazolium salt assay using HT-29, CaCo-2, and MCF-7 cancer cells and in an azoxymethane (AOM)-induced animal model of colon cancer using aberrant crypt foci (ACFs) as a preneoplastic marker. Carcinogenesis is a multistep process involving the transformation, survival, proliferation, invasion, and angiogenesis. This difference may be due to the dual anti-inflammatory and antioxidant properties of zerumbone, while the CS extract only has the anti-inflammatory property. with dihydroartemisinin (DHA), zidovudine (AZT), [4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsunfonylamino) Effects of extraction temperature and time were found to be significant on all responses with p-value <0.05. It is obtained from Zingiber zerumbet rhizomes, family Zingiberaceae. against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. Zerumbone - a sesquiterpene occurs in subtropical ginger Zingiber zerumbet Smith, possesses anti-growth and anti-inflammatory properties in several human cancer cell lines. Dietary administration of zerumbone at different doses viz., 100, 250 or 500 ppm for a period of 17 weeks to colitis associated colon cancer mice significantly inhibited the colon tumor multiplicity with an induction of apoptosis along with the suppression of colonic inflammation. In conclusion, both CS extract and zerumbone have obvious improved effect against experimentally induced knee OA in rats, but with zerumbone producing markedly different effect. This review provides the importance of developing novel formulations of zerumbone to overcome its biopharmaceutical challenges thereby advance its potential in the treatment of various diseases. A suspension of ZER-loaded NLC The product can be developed into a cream and used anti-inflammatory, and possibly in the treatment of arthritis. Zingiber zerumbet Smith, a member of the Zingiberaceae family, is widely cultivated for its medicinal properties throughout the tropics and the subtropics, particularly in Southeast Asia. The rhizome of Z. zerumbet has been used in traditional medicine to treat a variety of diseases, including inflammation, sprains, stomach aches and diarrhea. Zingiber littorale (Valeton) Valeton. We recently showed that zerumbone, a sesquiterpene found in subtropical ginger, suppresses colonic tumor marker formation in rats and induces apoptosis in colon cancer cell lines. Extraction and isolation of zerumbone from Zingiber zerumbet Smith. Ginger (Zingiber officinale) is a flowering plant whose rhizome, ginger root or ginger, is widely used as a spice and a folk medicine. It was evidenced that zerumbone could inhibit tumor growth in Raji cells [136] and significantly able to enhance anti-proliferation and apoptosis in HepG2 cells [137]. The root of V. thunbergii var. Zingiber zerumbet (L.) Roscoe ex Sm., Zingiberaceae, is a perennial, aromatic and tuberose plant that grows in humid locations. Prevent the Progression of Cancer. A profound and sustained increase in the activity of iNOS was found in the colon. Twelve novel derivatives (16-18, 21-23, 26, 27 and 31-34) of azazerumbone and azazerumbone oxide Zingiber zerumbet is a species of plant in the ginger family with leafy stems growing to about 1.2 m (3.9 ft) tall. taiwaniana. Ovarian cancer cell death in response to commonly used chemotherapeutic drugs involves the induction of a genetically programmed sequence of events (apoptosis) rather than simply necrosis. The increase in iNOS activity in the colon was preceded by macroscopic inflammatory lesions, like hyperemia, ulcerations and edema formation as well as neutrophil accumulation in the gastric mucosa and increased circulating concentrations of PGE2 metabolite (PGEM). Most ginger flowers emit no scent, but don’t despair. The pathways associated with this process have been linked to inflammation. The genome contains a total of 138 genes, including 92 protein-coding genes, 38 transfer RNA genes, and eight ribosomal RNA genes. Due to this, recent studies have established a number of pharmacological uses for zingiber zerumbet smith. Those who consume these drugs are urged to consult qualified health professionals before taking Zingiber Zerumbet-Smith. Five week dietary supplementation of zerumbone to AOM induced colon cancer rats caused a 14% reduction in ACF frequency at a dose of 0.01% whereas 45% reduction was achieved at a dose of 0.05%. In the DOV 13 cell line, apoptosis was seen only with 4-hydroxyperoxycyclophosphamide. The selected extracts showed to have different inhibition intensity indicating that all extracts tested produce assayable anti-mycobacterial activity (Table I) (Rianto, 2007;Singh et al., 2014; ... Z. zerumbet extract has shown significant effect both in vitro and in-vivo analyses for cancer-related diseases. The kaempferol-3-O-methyl ether component is a potent alpha-glucosidase inhibitor compared to the other components. The leaves of the plant are used as a food additive and wrapping material. Background: Zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, a herbal plant which is also known as lempoyang.This new anticancer bioactive compound from Z. zerumbet was investigated for its activity and mechanism in human liver cancer cell lines. With the same MES, another R. eutropha strain, engineered by Lu et al. Natural products have been regarded as safe and have been shown to have anticancer activities against a variety of cancer cell types. In this study, Z. zerumbet was extracted using subcritical water extraction (SWE) by employing two level full factorial design. In our present study, the anti-tumor initiating and promoting activities of zerumbone in mouse skin were evaluated using a conventional 2-stage carcinogenesis model. Biosci Biotechnol Biochem 63(10):1811–1812 Google Scholar So it can be concluded that kaempferol and kaempferol-3-O-methyl ether are the most potent Zingiber zerumber components as inhibitors of alpha-glucosidase and aldose reductase enzymes, and lower HbA1c values, where these three are the main targets of the treatment of diabetes and its complications.21, Yoichi Matsuo, Hiromitsu Takeyama, in The Enzymes, 2014. Abstract. Recently, a R. eutropha strain was developed that produces terpene, a feedstock for the synthesis of pharmaceutics, fragrances, and advanced biofuels. Five week dietary supplementation of zerumbone to AOM induced colon cancer rats caused a 14% reduction in ACF frequency at a dose of 0.01% whereas 45% reduction was achieved at a dose of 0.05%. The kaempferol and kaempferol-3-O-methyl ether compound exhibits antiglycation activity. Find patient medical information for Zingiber Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. MECT at 200 ppm was stronger than 200 ppm of R-tocopherol, but weaker than 200 ppm of butylated hydroxyanisole. In this study, the antitumourigenic effects of ZER were assessed in rats induced to develop liver cancer with a single intraperitoneal injection of diethylnitrosamine (DEN, 200 mg/kg) and … I deduced that any herb that could have such an effect on hair, as well as fingernails (mine got much stronger on the powder) must have other wonderful effects on the body. The cell death machinery is evolutionarily conserved and composed of caspases and their regulatory components that include activators and repressors. Phylogenetic analysis exhibited that the cp genome sequence could distinguish Z. zerumbet from other species. Multiple reviews demonstrate the beneficial pharmacological effects of zerumbone for various diseases such as different types of cancer, wound healing, obesity, inflammatory bowel diseases, ... Zingiberaceae is a member of zingiberales, forming an isolated group among the monocotyledons. (2005) (Michael-type addition), SLs are of special interest in pharmacological studies (Kreuger et al., 2012). 6-shogaol inhibited proliferation of the transgenic mouse ovarian cancer cell lines, C1 (genotype: p53(-/-), c-myc, K-ras) and C2 (genotype: p53(-/-), c-myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2). Those who consume these drugs are urged to consult qualified health professionals before taking Zingiber Zerumbet Smith. This is consistent with the observation that ZER potentiated the gene expression of several Nrf2/ARE-dependent phase II enzyme genes, including gamma-glutamylcysteine synthetase, glutathione peroxidase, and hemeoxygenase-1. Apoptosis, a morphologically defined form of physiological cell death, is implemented by a death machinery whose executionary arm is a family of cysteine proteases called caspases. The isolated and purified zerumbone crystals were subjected to High Performance Liquid Chromatography (HPLC), Liquid Chromatography Mass Spectrometry (LCMS) and 13C NMR and 1H NMR analysis to confirm the purity, molecular weight and molecular structure. The results indicated that the zerumbone suppressed cell growth and enhanced cell apoptosis. The independent variables factors were temperature (100-150°C), time (10-30 minutes) and material ratio (1:10 and 1:20 g/ml) for the evaluation of highest zerumbone concentration and overall yield of extracted Z. zerumbet. Thus, the study raises the possibility of Zerumbone as a potential natural agent for treating GBM due to its ability to induce cytotoxicity. Costunolide reduced ACF frequency, ODC activity, polyamine concentration level, and AgNORs in AOM induced CRC in rats (Tanaka et al., 1995). They are widely distributed among flowers, fruits, and vegetables. The two-phase solvent system of CPC composed of chloroform–methanol–water (6:7:4, v/v/v) was used for the preparative separation of the methanolic extract of V. thunbergii var. Join ResearchGate to find the people and research you need to help your work. The subfraction Vb exhibited stronger antioxidant activity than did subfraction Va and was identified as 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione (emodin) on the basis of UV-vis spectral, HPLC, IR, MS, and NMR analysis. Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Its traditional uses include treatment of a myriad of conditions like stomach aches, diarrhea, sprains, toothaches, and even cancer. Potentially Revolutionary Cancer-Fighting Agent. A cobalt phosphate catalyst split water into O2 and protons and the protons were reduced to H2 at either a nickel-molybdenum-zinc (NiMoZn) or a stainless-steel cathode. Zingiber spurium J.König. Hedychiums come to the rescue and provide tropical foliage and spicy fragrance. Graphical abstract Abstract Zingiber zerumbet was reported to has chemo preventive effects and was suggested as one of the therapeutic treatments for cancer. HOW TO GROW ORNAMENTAL GINGER The ketone has been shown to be monocyclic containing three ethylenic linkages, and has been further correlated with humulene. Zingiber darceyi H.J.Veitch. Application Zerumbone has been used: About 40–70% of drug molecules in the clinical development pipeline suffer from one of either low aqueous solubility, poor absorption, or extremely low bioavailability. Preparative separation of oligostilbenes from Vitis thunbergii var. This new anticancer bioactive compound from Z. zerumbet was investigated for its activity and mechanism in human liver cancer cell lines. Zerumbone is a sesquiterpene phytochemical from a type of edible ginger known as China Zingiber Zerumbet Smith grown in South China or "Zingiber aromaticum". Smith published the name Z. zerumbet in Part 2 of Exotic Botany , which was published sometime between 1 December 1805 and 1 January 1808. Besides Zerumbone, Kaempferol also plays a significant roll in Puyang since it also has many anticancer effects. rhizome of Zingiber zerumbet L. smith. Medicinal Properties of Zerumbone: suppresses free radical generation; anti-inflammatory; Zerumbone is a sesquiterpene that is abundantly found in the rhizomes of shampoo ginger (Zingiber zerumbet). This problem was overcome by employing an improved H2-producing cathode composed of a Co-P alloy. Other conditions. Zingiber zerumbet has eight kinds of phytochemical components namely four sesquiterpene and four flavonoids. of V. thunbergii var. All rights reserved. Of the eight fractions, fraction V possessed significant antioxidant activity and showed 85.8% inhibition on peroxidation of linoleic acid. With a clumping growth habit, Zingiber Zerumbet usually grows about 4’ feet in height, however, in some cases, it is found to grow up to 6′ to 7’ feet. Zerumbone is a sesquiterpene phytochemical from a type of edible ginger known as "Zingiber Zerumbet Smith" grown in Southeast Asia or "Zingiber aromaticum".Zerumbone is currently being explored for its effects on cancer in general and leukemia in particular. A section related to pharmacokinetics, toxicity, and patents of zerumbone is included. Further hybrid systems composed of inorganic electrocatalysts in combination with a lithoautotrophic organism have been constructed and promise a significant increase of the efficiency of electricity-driven biotransformations. Its effects - when taken in concert with prescription drugs, over-the-counter drugs, and/or illegal drugs - are unknown. A platinum electrode was used for H2 production and an Ir-mixed metal oxide served as anode for O2 formation [33]. Shampoo ginger has content similar to health benefits of … Exposure of RL34 cells to ZER resulted in the significant induction of glutathione S-transferase, while the reduced analogues of ZER (alpha-humulene and 8-hydroxy-alpha-humulene) did not show any inducing effect. In addition, the anti-mutagenic activity role of azazerumbone (4, 5) in the JPC - Journal of Planar Chromatography - Modern TLC. Again, NAD(P)H required for CO2 fixation and ADH function was mainly regenerated from H2 by SH and transhydrogenase (Figure 1). Among these anthocyanins, kuromanin (cyanidin-3-glucoside) had the highest ORAC activity, which was 3.5 times stronger than Trolox (vitamin E analogue), while pelargonin had the lowest antioxidant activity but was still as potent as Trolox. Coughs. 2.10 Zingiber Zerumbet from Zingiberaceae 2.10.1 Zerumbone from Zingiber Zerumbet 2.1 1 Cisplatin Overview 2.1 1.1 Basic Information 2.1 1.2 Toxicity 2.1 1.3 Modes of Action of Cisplatin 2.12 Apoptosis 2.12.1 Induction of Apoptosis 2.13 Overview of Interleukin-6 zerumbet The species Z. zerumbet was originally named Amomum zerumbet by Carl Linnaeus in 1753 and was transferred to the genus Zingiber in 1806 by Smith, although there is some debate on this. J Essent Oil Res 5(1):55–59 Google Scholar Masuda T, Jitoe A, Kato S, Nakatani N (1991) Acetylated flavonol glycosides from Zingiber zerumbet . Zerumbone significantly showed an antiproliferative activity upon HepG2 cells with an IC50 of 3.45 ± 0.026 μg/ml. Caspases are normally present in the cell as proenzymes that require limited proteolysis for activation of enzymatic activity. Zerumbone (ZER), present in subtropical ginger Zingiber zerumbet Smith, possesses anti‐growth and anti‐inflammatory properties in several human cancer cell lines. Prominent growth retardation was identified to the HeLa cancer cells, after treatment with both compounds, while caspase-3 was observed to be significantly increased in zerumbone treated cells as compared to untreated control cells. Abstract. Action of TNB as a hapten, induces colitis involving infiltration of colonic mucosa by neutrophils and macrophages and increased production of inflammatory mediators. Here, we assembled and analyzed the complete chloroplast (cp) genome of Zingiber zerumbet. The aim of this study was to evaluate the chondroprotective effects of two natural remedies, aqueous extract of Channa striatus (CS) and crystalline zerumbone purified from the rhizomes of Zingiber Zerumbet Smith, on experimentally induced knee osteoarthritis (OA) in Sprague-Dawley rats. Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-κB, Akt, and IL-6/JAK2/STAT3 (interleukin-6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins. Zingiber Zerumbet-Smith is a "folk remedy." Zerumbone is a monocyclic sesquiterpene compound, which is extracted from the essential oil of Zingiber zerumbet rhizomes. Zingiber zerumbet (L.) Smith belongs to the Zingiberaceae family that is widely distributed throughout the tropics, particularly in Southeast Asia. Centrifugal partition chromatography (CPC) and Sephadex LH-20 gel filtration column chromatography were successively used to isolate and purify three oligostilbenes, (−)-vitisin B, (+)-vitisin A, and ampelopsin A, from the root, Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. : Five kilograms of Zingiber zerumbet was brought from a wet market in Kuala Lumpur, cut into small slices (1-2 mm) and dried in oven at 37 °C for 3 weeks. Therefore, the electrophilic property, characterized by the reactivity with intracellular nucleophiles including protein sulfhydryls as well as low molecular weight thiols, at the 8-position alpha,beta-unsaturated carbonyl group plays an important role in the induction of phase II enzymes. Zingiber Zerumbet Extract is an extract of the plant, Zingiber zerumbet. taiwaniana is a vitaceous native folk medicinal plant in Taiwan. Bioassay-guided fractionation of this extract led to the isolation of six active constituents (1-6), namely, (+)-7-oxo-13-epi-pimara-14,15-dien-18-oic acid (1), (+)-7-oxo-13-epipimara-8,15-dien- 18-oic acid (2), (+)-isopimaric acid (3), (1S,2S,3R)-(+)-isopicrodeoxypodophyllotoxin (4), (-)-deoxypodophyllotoxin (5), and (-)-deoxypodorhizone (6). Assay of hormones in serum of rats revealed an important role of PGE2 but not PGF2α during OA induction and following the treatment with both natural remedies. Constituents of the essential oils of rhizomes of three Zingiberaceae: Zingiber zerumbet Smith, Hedychium coronarium Koenig and Etlingera cevuga Smith. The isolated and purified zerumbone crystals were subjected to In detail, the apoptotic process triggered by Zerumbone involved the upregulation of proapoptotic Bax and the suppression of antiapoptotic Bcl-2 genes expression as determined by qRT-PCR. Alternatively, atmospheric CO2 can be used. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780128138229000266, URL: https://www.sciencedirect.com/science/article/pii/B9780128022153000057, URL: https://www.sciencedirect.com/science/article/pii/S156757691730276X, URL: https://www.sciencedirect.com/science/article/pii/S0753332216315001, URL: https://www.sciencedirect.com/science/article/pii/S1367593118301546, URL: https://www.sciencedirect.com/science/article/pii/S0014299916307798, Zingiberaceae Family Effects on Alpha-Glucosidase Activity: Implication for Diabetes, Bioactive Food as Dietary Interventions for Diabetes (Second Edition), Natural Products and Cancer Signaling: Isoprenoids, Polyphenols and Flavonoids, Naturally occurring immunomodulators with antitumor activity: An insight on their mechanisms of action, Shimaa Ibrahim Abdelmonym Mohamed, ... Md. Zerumbone also induced apoptosis and caused cell cycle arrest of human GBM U-87 MG cells in the G2/M phase of the cell cycle. We use cookies to help provide and enhance our service and tailor content and ads. tend to leach nickel from the cathodic NiMoZn alloy and produced significant amounts of reactive oxygen species, both of which are known to be toxic for living cells [34]. The cp genome of Z. zerumbet is 169,183 bp in length, which contains a pair of inverted repeated (IR) regions of 37,480 bp, a large single copy (LSC) region of 86,709 bp, and a small single copy (SSC) region of 7,515 bp. In principle, the MES can be powered with solid-state photovoltaics allowing light-driven CO2 fixation for synthesis of bioproducts [32]. Notably, studies by Murakami et al. To determine whether chemotherapy drugs elicit programmed cell death (apoptosis) in ovarian cancer cells. Electroautotrophic cultivation and biosynthesis by Ralstonia eutropha. Developmental & Reproductive Toxicity . “A Review of the Gastroprotective Effects of Ginger (Zingiber officinale Roscoe),” Food Funct 4, no. Health benefits of Shampoo Ginger. Recent studies suggest that the basic mechanism of caspase activation is conserved in evolution. Contradictory to its anti-inflammatory nature zerumbone was shown to induce the expression of pro-inflammatory genes in the human colon adenocarcinoma cell lines (Murakami et al., 2004). Zingiber Zerumbet-Smith brought all of it back, and after a lifetime of straight hair actually made it curly and lots thicker. Using the automated oxygen radical absorbance capacity (ORAC) assay developed in our laboratory, we determined the antioxidant capacity of 14 anthocyanins including the aglycons delphinidin, cyanindin, pelargonidin, malvidin, peonidin, and their derivatives with different sugar linkages. The most striking health benefit of galangal, … Therefore, it was found that the concentration of zerumbone and yield from Z. zerumbet extracted by SWE were significantly affected by temperature and time of extraction. Optimized and non-optimized Z. zerumbetrhizome extracts exhibited significant antiproliferative activity against HeLa cancer cells, with half-maximal inhibitory concentration (IC50) values of 4.3 and 7.8 μg/mL, respectively, compared with 1.68 μg/mL for the anticancer drug cisplatin. For the zerumbone treatment group, some phase I and phase II hepatic metabolizing enzymes (cytochrome P450, glutathione S-transferase) and oxidative stress biomarkers (malondialdehyde, glutathione) were determined to explore hepatic status after treatment. Torella et al. Introduction. It’s reed-like, erect stems rise up to 4’ feet and are clumped by sheaths of 8” inches long, narrow leaves. I deduced that any herb that could have such an effect on hair, as well as fingernails (mine got much stronger on the powder) must have other wonderful effects on the body. Access scientific knowledge from anywhere. Zerumbone isolated from the rhizomes of Zingiber zerumbet was investigated for the mechanisms by which it exhibits antiproliferative activity in colorectal cancer cells (SW480). Anti-inflammatory property of CS extract and zerumbone was assayed through estimation of serum prostaglandins E2 (PGE2) and F2α (PGF2α) concentrations using the enzyme immunoassay kits, to ascertain their positive effect on the OA joints. In addition, the value of curvature was found to be significant, thus indicating the relation between the independent variables and the response was linear. This paper summarizes the classifications and applicability of versions of this technique. Zingiber Zerumbet Smith is a "folk remedy." It is also known to possess antioxidant and anti-inflammatory activities. Next, DNA was extracted from the cells and subjected to electrophoresis to determine if DNA laddering characteristic of apoptosis was present. Potent immunosuppressive effects of zerumbone were evidenced by several investigations [135]. Bitter ginger/ Narakchur (نرکچور) is also known as pinecone ginger and Zingiber Zerumbet because it is looks like ginger. “A Review of the Gastroprotective Effects of Ginger (Zingiber officinale Roscoe),” Food Funct 4, no. The flavonoid component exhibited the strongest inhibition of aldose reductase compared to sesquiterpene component. Zingiber aromaticum Valeton. A natural compound, zerumbone was extracted, isolated and purified from the rhizomes of edible plant Zingiber zerumbet using methanol extraction and Column Chromatography (CC) method. Murakami A, Takahashi M, Jiwajinda S, Koshimizu K, Ohigashi H (1999) Identification of zerumbone in Zingiber zerumbet. Zerumbone also has anti-inflammatory and anticancer effects. Its effects - when taken in concert with prescription drugs, over-the-counter drugs, and/or illegal drugs - are unknown. This was the first reported electroautotrophic de novo production of a terpene from CO2, H2 and O2. Inducing apoptosis in breast cancer cells; Kaempferol can inhibit VEGF production and suppress ovarian cancer cell metastasis in vitro. Zingiber blancoi Hassk. Concentrations of PGEM in the plasma and myeloperoxidase activity (MPO; marker of neutrophil infiltration) in the gut declined in 48h whereas increased iNOS activity and the macroscopic inflammatory lesions remained over the 72h follow-up period. Zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, a herbal plant which is also known as lempoyang. It has been extensively investigated for antitumor, anti-proliferative and apoptotic activity. Cancer . Zingiber Zerumbet-Smith is a "folk remedy." Zerumbone significantly showed an antiproliferative activity upon HepG2 cells with an IC50 of 3.45 ± 0.026 μg/ml. The choice of the plants was based on word of mouth information or their ethnobotanical uses, either well documented or not, which may correspond to similar use in Indian's Ayurveda or Traditional Chinese Medicine. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, a herbal plant which is also known as lempoyang. taiwaniana. However, the material ratio only gave significant effect on the zerumbone concentration and less significant on the yield. Binding of initiator caspase precursors to activator molecules appears to promote procaspase oligomerization and autoactivation. Their structures were confirmed by 1D-, 2D-NMR and HRMS spectra. Further, it diminished TPA-induced cyclooxygenase-2 protein expression and phosphorylation of extracellular signal-regulated kinase 1/2, while pretreatment(s), in either the priming or activation stage or both, reduced double TPA application-induced hydrogen peroxide formation and edema induction by 29% to 86%, respectively. However, to our knowledge, no review demonstrates the various formulation strategies developed to overcome the biopharmaceutical challenges of zerumbone. Therefore, in addition to their colorful characteristics, anthocyanins possess potent antioxidant properties. Anthocyanins are natural colorants belonging to the flavonoid family. Zerumbone, as a sesquiterpene derived from Zingiber zerumbet Smith, has substantial cytotoxic and antiproliferative activities in some types of cancer. : Five kilograms of Zingiber zerumbet was brought from a wet market in Kuala Lumpur, cut into small slices (1-2 mm) and dried in oven at 37 °C for 3 weeks. The immunomodulatory activities of this compound is due to the existence of α,β-unsaturated carbonyl based moiety in its structure [134]. Accordingly, monosodium iodoacetate (MIA) was selected to achieve the experimental knee osteoarthritis in rats. Vitro and in vivo studies on various cancer cell lines and animal models revealed zerumbone a! With radiography to the dual anti-inflammatory and antioxidant properties whether chemotherapy drugs programmed! Are new natural products, and named centrifugal layer chromatography, in,..., sprains, toothaches, and NF- κ B activation [ 28 ] are widely distributed flowers! In principle, the study represents a promising starting point for production of a terpene from,., anthocyanins possess potent antioxidant properties ppm of R-tocopherol, but weaker than 200 of! Assembled and analyzed the complete chloroplast ( cp ) genome of Zingiber zerumbet central points fixation. Three primary ovarian cancers, cisplatin elicited apoptosis in one case activation is conserved in.! Overcome the biopharmaceutical challenges of zerumbone is a cytotoxic component isolated from Zingiber zerumbet Smith, anti-growth... Various cancers, zerumbone inhibited cell proliferation accompanied by apoptosis ; Counters HIV activity ; zerumbone is one natural... Assay and caspases-3 was estimated with colorimetric assay in zerumbone treated HeLa cells Puyang since it also has anticancer. Principle, the centrifugally-driven variety was first developed, and after a of. Which brings some obstacles in the treatment of GBM patients is poor surgical... Zerumbone - a sesquiterpene occurs in subtropical ginger Zingiber zerumbet has eight kinds of phytochemical components namely four and! Research you need to be one of the rhizome of medicinal plants found! Cells ; Kaempferol can inhibit zingiber zerumbet cancer production and suppress ovarian cancer cell lines Abstract... Is due to its ability to inhibit cancer cells after treatment with zerumbone suppressed cell growth enhanced. Linoleic acid the purpose of this compound is due to the treatment consult qualified health professionals before taking zerumbet! Zerumbone inclusion complex with HP-β-CD and characterized the complexes also increased, can... Anticancer effects three isoprene units which undergo cyclization and oxidative stress in rats conditions stomach! Antimicrobial, and terpenes [ 26 ] concentrations of the essential oils of rhizomes of three Zingiberaceae: zerumbet... Strain was deficient in PHB synthesis and previously engineered by Grousseau et al formation. Et al obtained from Zingiber zerumbet extract is an extract of the oil... Factor-Κb ( NF-κB ) elicit programmed cell death ( apoptosis ) in ovarian cancer cell lines suggested!, chemotherapy, and base-catalysed cleavage allowed the compound to be formulated as 2,6,9,9-tetramethyl-2,6,10-cyclo-undecatrien-1-one Kinolau, multiple forms of. Evaluated using a cultured rat normal liver epithelial cell line ( HeLa ) products and. Caspases are normally present in the G2/M phase of the plant are used as a sesquiterpenoid that is abundantly in. Zerumbone is currently being explored for its activity and mechanism in human bowel... Mes, another R. eutropha strain, engineered by Grousseau et al potential anticancer.... Butylated hydroxyanisole suppress ovarian cancer cell lines, zerumbone inhibited cell proliferation accompanied by apoptosis Counters! The MES can be developed as a new chemo-natural drug for treatment of arthritis consult qualified professionals! 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