The efficacy of an inactivated vaccine for the treatment of feline dermatophytosis was investigated in a placebo-controlled-double-blind multi-centre GCP study in Europe. The treatment of dermatophytosis by the inactivated vaccine Insol®Dermatophyton was studied in eleven German counties between the end of 1997 and the beginning of March 1999. For active immunisation of horses, dogs and cats against dermatophytosis caused by Trichophyton verrucosum, Trichophyton mentagrophytes, Trichophyton sarkisovii, Trichophyton equinum, Microsporum canis and Microsporum gypseum for the purpose of reducing the risk of a clinical infection due to these fungal species, and as a therapeutic measure for accelerating the healing of clinically visible skin … Your doctor might be able to diagnose ringworm simply by looking at it. Tinea can also spread from one part of the body to another (for example, a patient with tinea pedis can go on to develop tinea cruris). Some of the patients were pretreated either with enilconazol or with an inactivated vaccine against dermatophytosis. ; The medical term for ringworm is tinea.The skin disease is further named for the site of the body where the infection occurs. The primary endpoint was not met for the total population of cats, but was met for cats < one year of age and for cats with a first infection. Join ResearchGate to find the people and research you need to help your work. Since the end of the sixties, trials of immunization against dermatophytosis were performed. Ringworm, also called dermatophytosis or tinea, is a fungal infection of the skin. With cattle, systemic vaccination has achieved effective control of ringworm. Vaccination induced a strong antibody response, and a significant but transient lymphoproliferative response against the protein. The treatment of dermatophytosis by the inactivated vaccine Insol®Dermatophyton was studied in eleven German counties between the end of 1997 and the beginning of March 1999. weeks after the first of two recommended applications all horses showing clinical symptoms of dermatophytosis at the time of the primovaccination had recovered clinically. A control group of 6 horses was injected with saline solution as placebo. Since 1979 a Russian live vaccine (LFT 130) and later on a Czechoslovakian live vaccine against bovine ringworm has been used. 90% of the challenged areas showed the typical clinical symptoms of dermatophytosis after 2 - 3 weeks. There are many types of fungal germs (fungi) and some can infect the skin, nails, and hair. The use of INSOL(R) DERMATOPHYTON can be recommended in comparable breeding-situations without any restrictions. It’s called “ringworm” because it can cause a circular rash (shaped like a ring) that is usually red and itchy. Indication Cultures were prepared from the samples in Sabouraud's dextrose agar and incubated at 25°C. Ringworm is itchy, scaly, and contagious. Treatment of feline dermatophytosis with an inactivated fungal vaccine. Despite its name, it is a fungal infection having nothing at all to do with worms. Insol® Dermatophyton contains immunogenic strains of fungus. All of the horses were clinically investigated the day before vaccination as well as the 10 following days. © 2008-2020 ResearchGate GmbH. Sometimes the rash is itchy. The vaccine was significantly better than placebo in cats with a first infection (sum of lesions: p = 0.0446; summed score x number: p = 0.0405) and in young cats (sum of lesions: p = 0.0424; summed score x number: p = 0.0304; mean score x number: p = 0.0177). To date only a single live vaccine against cattle ringworm has been used with success. In a stud a large number of horses of different ages and both sexes fell ill with clinical symptoms of dermatophytosis in summer/autumn of 1996. Results of the vaccination demonstrated that within six weeks after the first of two recommended applications all horses showing clinical symptoms of dermatophytosis at the time of the primovaccination had recovered clinically. It is caused by a fungal infection—not an actual worm. Vaccines as prophylactic or therapeutic treatment against dermatophytosis have been developed for cattle, horses, foxes, guinea pigs, cats and dogs [20][21][22][23], ... An inactivated M. canis vaccine (Fel-O-Vax 0 MC-K, Fort Dodge, IA, USA), which is marketed in the USA for both prevention and treatment of feline ringworm, seems to have poor e⁄cacy [13]. Rocky Mountain Spotted Fever in Dogs. Treatment of Feline Dermatophytosis with an Inactivated Fungal Vaccine~!2009-10-15~!2010-01-26~!2010-04-07~! Insol® Dermatophyton contains the preservative Thiomersal. Severely affected exotic cats also showed an improvement using these parameters. 55 client-owned cats with dermatophytosis caused by Trichophyton mentagrophytes or Microsporum canis, confirmed by fungal culture, were treated with either three intramuscular injections of vaccine or placebo. The design of an effective vaccine against dermatophytosis appears to require the induction of cellular rather than humoral immunity. Micanfin (Biocan-M®, Bioveta) is a new veterinary drug used successfully in the treatment and prophylaxis of Dermatomycosis in dogs and cats. 5 weeks after the first vaccination protection is complete and will last for at least 9 months. Scalp: On the scalp, ringworm requires prescription medicine. (It is not due to a worm as its name implies!) Recent progress in vaccinology, particularly in the field of subunit vaccines and adjuvants, as well as a better understanding of the pathogenesis of dermatophytosis could allow further development of effective vaccines against these diseases, notably in dogs and cats. The cat had a history of diffuse alopecia which had not responded to two weeks of oral antimycotic therapy, three weeks before presentation. Efficacy was evaluated for the reduction of the number of lesions as well as for a combined assessment of lesion severity x number of lesions. For example, a vaccine against dermatophytosis (Insol Dermatophyton, Boehringer Ingelheim, Germany) also known as ringworm, a disease that can be transmitted between animals and humans, has been approved in many European countries for therapeutic or prophylactic use in dogs, cats, and horses. Ringworm (Tinea) Guide: Causes, Symptoms and Treatment Options The primary endpoint was not met for the total population of cats, but was met for cats <1 year of age and for cats with a first infection. Dermatophytosis is the contagious superficial infection of the skin caused by dermatophytes (ringworm or tinea) which is the most common skin disease in horses. To read the full-text of this research, you can request a copy directly from the authors. You may need stronger medicine. Characteristics The use of the vaccine as a teatment for dermatophytosis can be classified as very successful. There is no specific vaccination for Sweet Itch however European anecdotal reports have suggested that a Ringworm Vaccine (Insol Dermatophyton) can aid in reducing the severity of Sweet Itch and we have seen excellent results with this vaccine over the years. A live-trichophyton vaccine against ringworm in cattle which was based on an attenuated strain of Trichophyton verrucosum was tested in controlled challenge-exposure experiments and in field trials. In the safety study 29 healthy horses were immunised pro-phylactically with two injections of 5 ml HippoTrichon® at an interval of 2 weeks. Based on this study, the investigated inactivated vaccine may be considered as part of a treatment protocol to accelerate healing from clinical signs of dermatophytosis in severely affected cats, in young cats and those with a first infection. Ringworm is a fungal parasite that causes skin disease in pets and people. In cattle for example such negative parameters are the general immunity situation and the status of health, seasons and climate, quality of animal housing, disease situation and risk of infection as well as vaccination programs. There are many types of dermatophytes, but most cases of canine ringworm are caused by one of three species. All of the horses were treated twice at an interval of 2 weeks with a deep intramuscular injection of 5 ml HippoTrichon®. The pentavalent, inactivated, non-adjuvanted vaccine (Insol Microsporum) was formulated as an aqueous solution containing 10 × 10 6 to 12 × 10 6 microconidia of each of the following five fungal strains: T mentagrophytes (strain 1032), M canis (strain 1393), M canis var distortum (strain 120), M canis var obesum (strain 1311) and M gypseum (strain 59), and 0.04 mg … The use of INSOL® DERMATOPHYTON can be recommended in comparable breeding-situations without any restrictions. A successful therapy of trichophytosis is noticed because of its good efficacy not only in horses treated for the first time but also in pretreated and chronically sick animals. Application Clinical symptoms were assessed at inclusion, day 14, 28 and 42. The first signs of infection on the body are red, scaly patches. All rights reserved. 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